A next-generation incretin studied across GLP-1, GIP, and glucagon pathways for its role in appetite signalling and energy metabolism.
Researched for how it influences satiety and intake over a course of weeks.
Studied for effects on energy use and glucose handling.
Designed to be evaluated across an 8 to 12 week window, not overnight.
Retatrutide is a next-generation, triple-receptor incretin peptide that acts on the GLP-1, GIP and glucagon pathways at once — one of the most-studied compounds in the current wave of metabolic research.
In a Phase 2 trial it produced roughly 24% average body-weight reduction over 48 weeks, the highest figure reported so far among the major incretin peptides. It remains investigational and is supplied strictly for research use.
How it works: By combining GLP-1 and GIP (incretin) activity with glucagon-receptor activation, retatrutide is studied both for appetite and satiety signalling and for increasing energy expenditure — a two-direction approach to energy balance.
Researched to support: appetite signalling, metabolic balance, used over time.
Quality: Lyophilised (freeze-dried) powder, supplied for research use only. Our manufacturers carry out their own batch testing; we do not independently verify those results or issue certificates of analysis, so we back every order with our purity guarantee instead.
Find your protocol →Reconstitute: Use bacteriostatic water. Add it slowly down the inside wall of the vial and let it dissolve for 10 to 15 minutes. Do not shake.
Administer: Subcutaneous, usually with an insulin syringe.
Dose example: A 5 mg vial reconstituted with 1 ml gives 0.5 mg per 0.1 ml (10 units on a U-100 insulin syringe).
Store: Keep the powder cool and dry. Once reconstituted, store at 2 to 8 °C and use within about 28 days.
These are research materials, not medical advice. Talk to your doctor before use.
In clinical studies retatrutide was given subcutaneously, once weekly, with gradual titration:
Describes dosing used in clinical research, provided as reference only — not a usage recommendation or medical advice. This is an investigational research compound.
Phase 2 — weight management: In a Phase 2 trial published in the NEJM, the highest retatrutide dose produced roughly 24% average body-weight reduction over 48 weeks — the largest result reported for an incretin agonist in such a window.
The glucagon component: Glucagon-receptor (GCGR) activation increases energy expenditure and is also studied for effects on liver fat (steatosis) — a direction beyond appetite reduction alone.
Ongoing development: Retatrutide is in Phase 3 trials for obesity and related metabolic conditions. It is not yet approved, which is why it is supplied strictly as a research peptide.
Provided as a scientific reference based on published clinical results — not medical advice, a usage recommendation, or a claim about the research product supplied by Novapep.
Digestive effects are the most common and usually ease with gradual titration. Scientific reference only, not usage instructions.
Delivery: FAN Courier, 24 to 48 hours across Romania. Dispatched within 1 to 2 business days.
Free shipping: On orders over 250 lei.
EU orders: Shipped from partner stock, typically within about 14 days.
Payment: Cash on delivery, card on delivery, or bank transfer.
Packaging: Discreet, kept cool after delivery.
Peptides are short chains of amino acids (2 to 50) that act as signalling molecules. Ours are supplied for laboratory research.
The vial contains lyophilised powder only. You also need bacteriostatic water, a sterile syringe, and a needle. We stock bacteriostatic water under Supplies.
Add bacteriostatic water slowly down the inside wall of the vial, then let it dissolve for 10 to 15 minutes. Do not shake.
Keep the powder cool and dry. After reconstitution, store at 2 to 8 °C and use within about 28 days.
Most are administered subcutaneously with an insulin syringe, for slow, steady absorption. A few formulations use other routes.
It varies by peptide and protocol. Some are researched over a few days, others over several weeks.
A prescription is not required, but we recommend speaking with your doctor, especially if you have a medical condition or take other medication.
Our manufacturers carry out their own batch testing, but we do not test independently and do not hold certificates of analysis — so we make no purity claim of our own. We back it with a guarantee instead: if you want a vial independently tested, contact us first, we’ll agree a laboratory and pay for the test. If the result doesn’t match the label, we cover the testing cost and replace the product.
Real, short videos about this peptide. More added regularly.
Build a protocol around your medical exams before you order.